This study shows that MECOM mutations impair DNA binding and functionally antagonize GATA2, promoting leukemia and inhibiting mast cell differentiation.

Leukemia · May 5, 2026Peer-reviewedMolecular Biology

Differentiation stage-specific use of cap-independent and cap-dependent translation initiation in hematopoiesis

Michael C. Mazzola, Ting Zhao, Anna Kiem, Trine Ahn Kristiansen, Karin Gustafsson, Lai Ping Wong, Emily Scott-Solomon, Marissa D. Fahlberg, Sarah Forward, Emane Rose Assita, Giulia Schiroli, Maris Handley, Youmna Sami Kfoury, Tsuyoshi Fukushima, Samuel Keyes, , David T. Scadden

The paper shows that IRES/Cap translation increases during hematopoietic and epithelial differentiation under normal conditions, correlating with lower stemness.

bioRxiv · Sep 24, 2025 · PreprintDevelopmental Biology

Plcl1 Regulates Hematopoietic Stem Cell Function During Aging and Stress by Modulating Calcium Dynamics

Tomohiro Yabushita, Yosuke Tanaka, Tsuyoshi Fukushima, Kanako Wakahashi, Terumasa Umemoto, Hitoshi Takizawa, Susumu Goyama, Toshio Kitamura, Akira Nishiyama, Tomohiko Tamura, Satoshi Yamazaki, Toshio Suda

This study identifies Plcl1 as a regulator of calcium dynamics in hematopoietic stem cells, affecting their function during aging and stress.

bioRxiv · Sep 15, 2025 · PreprintCell Biology

Interrupting ELMSAN1 repression of nuclear Acetyl-CoA production therapeutically reprograms cancer cells

Ting Zhao, Lingli He, Lai Ping Wong, Shenglin Mei, Jun Xia, Yanxin Xu, Jonathan G. Van Vranken, Michael C. Mazzola, Lei Chen, Catherine Rhee, Tiancheng Fang, Tsuyoshi Fukushima, Leanne C. Sayles, Matthew Diaz, J. Alex B. Gibbons, , David T. Scadden

The paper identifies ELMSAN1 as a repressor of nuclear acetyl-CoA production and shows that inhibiting this interaction reprograms cancer cells to a postmitotic state, improving survival in multiple cancer models.

bioRxiv · Apr 25, 2025 · PreprintCancer Biology

Hematopoietic stem cells undergo bidirectional fate transitions in vivo

Tsuyoshi Fukushima, Trine Ahn Kristiansen, Lai Ping Wong, Yosuke Tanaka, Masaki Yagi, Yu-Hsuan Chang, Takaharu Kimura, Samuel Keyes, Michael C. Mazzola, Ting Zhao, Lingli He, Susumu Goyama, Ryō Yamamoto, Konrad Hochedlinger, Satoshi Yamazaki, , David T. Scadden

This study reveals bidirectional fate transitions between myeloid-biased and lineage-balanced hematopoietic stem cells using clonal phylogenetic tracing.

bioRxiv · Feb 23, 2025 · PreprintCell Biology