Keita Yamamoto

The paper develops CRISPR/Cas13-based tools to analyze RNA-protein interactions by integrating existing PPI methods with RNA-targeting Cas13, demonstrating their utility in studying paraspeckles.

This study shows that MECOM mutations impair DNA binding and functionally antagonize GATA2, promoting leukemia and inhibiting mast cell differentiation.

This study shows that ASXL1 mutations in mice promote atherosclerosis by dysregulating innate immunity through impaired inhibition of NF-κB signaling.