Shuhei Asada

This study shows midbody inheritance in HSCs delays re-entry into the next cell cycle but does not affect lineage potential.

This study identifies a defect in MMEJ repair in SMARCB1-deficient tumors, leading to hyper-dependence on the FA/BRCA pathway, which can be targeted for therapy.

The paper develops a DNA barcoding-based method to analyze HSC daughter cell pairs, revealing biased division patterns toward symmetric divisions and linking these to molecular features.

This paper shows that Ewing sarcoma cells have reduced POLθ expression and MMEJ activity due to EWS-FLI1 or EWSR1 disruption, making them sensitive to inhibitors of FA, NHEJ, or HR pathways.

This paper identifies a PIP motif in RAD18 essential for PCNA ubiquitination and shows USP1 inhibition leads to synthetic lethality in BRCA1-deficient cells.

This study shows that MECOM mutations impair DNA binding and functionally antagonize GATA2, promoting leukemia and inhibiting mast cell differentiation.

This study shows HPV16 E6 oncoprotein increases POLQ levels via UBE3A and RAD23A regulation, enhancing MMEJ to promote viral integration and oncogenesis.

This study shows that ASXL1 mutations in mice promote atherosclerosis by dysregulating innate immunity through impaired inhibition of NF-κB signaling.