Author

McKenna R. Casey

University of Colorado Anschutz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:statistical model· 1

Frequent Co-Authors

Kristen L. WellsiD· 2 shared Lori SusseliD· 2 shared Christopher J. Hill· 1 shared Cole R. MicheliD· 1 shared Dylan SarbaughiD· 1 shared Elliott P. BrooksiD· 1 shared Madeline Van Orman· 1 shared Michelle A. Guney· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersDevelopmental Biology

Kristen L. WellsORCID

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2 papers

Recent·Most cited

CHD4 and NKX2.2 Cooperate to Regulate Beta Cell Function by Repressing Non-Beta Cell Gene Programs

Dylan Sarbaugh, Thais Gaia Oliveira, Michelle A. Guney, McKenna R. Casey, Victoria M. Hoelscher, Christopher J. Hill, Cole R. Michel, Kristen L. Wells, Richard K.P. Benninger, Lori Sussel

This study identifies CHD4 as a cofactor of NKX2.2 that regulates beta cell function by repressing non-beta cell gene programs, leading to diabetes when disrupted.

bioRxiv · Jun 16, 2025 · PreprintDevelopmental Biology

NKX2.2 and KLF4 cooperate to regulate alpha cell identity

Elliott P. Brooks, McKenna R. Casey, Kristen L. Wells, Tsung-Yun Liu, Madeline Van Orman, Lori Sussel

This study identifies KLF4 as a novel factor that cooperates with NKX2.2 to regulate alpha cell identity by co-occupying promoters and modulating chromatin accessibility.

Genes & Development · Feb 1, 2025Peer-reviewedDevelopmental Biology