Lori Sussel

The paper identifies carbamylation as a regulatory modification in β-cell metabolism and insulin processing in T1D by analyzing proteomic changes in NOD and MIN6 cells.

The paper identifies how NKX2-2 independently controls neurogenesis and dorsoventral patterning in human spinal progenitors through distinct mechanisms from rodents.

This study optimizes single-cell long-read sequencing protocols for improved isoform detection in pancreatic islets, showing better transcript identification and longer reads through library preparation and transcript depletion strategies.

This study shows NKX2.2 is not required for endocrine specification but is needed for resolving endocrine fates in human pancreatic progenitors.

This study identifies CHD4 as a cofactor of NKX2.2 that regulates beta cell function by repressing non-beta cell gene programs, leading to diabetes when disrupted.

This study identifies meningeal-derived retinoic acid's role in suppressing Notch and Sox2 to regulate neurogenesis in neocortical progenitors.

This study identifies KLF4 as a novel factor that cooperates with NKX2.2 to regulate alpha cell identity by co-occupying promoters and modulating chromatin accessibility.

The paper investigates lipid composition changes in insulitis models and identifies ARH3 as a regulator of beta-cell apoptosis through PLA2G6 signaling.