Richard K.P. Benninger

Nonviral, ultrasound-triggered gene delivery platform via gas-core cationic nanobubbles

This paper develops a nonviral, ultrasound-triggered gene delivery platform using cationic nanobubbles that achieve efficient, site-specific gene expression in vitro and in vivo.

Laminin-511 protects pancreatic β-cells from cytokine-induced death through integrin-mediated pro-survival signaling and modulation of protein kinase C δ

This study shows laminin-511 protects β-cells from cytokine-induced death by activating Akt signaling and reducing PKCδ activity through membrane DAG modulation.

Diminished gap junction coupling under diabetogenic conditions does not drive loss of functional beta-cell sub-populations

This study shows that restoring gap junction coupling does not fully recover functional beta-cell sub-populations under diabetogenic conditions.

CHD4 and NKX2.2 Cooperate to Regulate Beta Cell Function by Repressing Non-Beta Cell Gene Programs

This study identifies CHD4 as a cofactor of NKX2.2 that regulates beta cell function by repressing non-beta cell gene programs, leading to diabetes when disrupted.

CRISP: Correlation-Refined Image Segmentation Process

CRISP improves cell segmentation accuracy in dense calcium imaging data by refining user-drawn masks and automatically identifying cell outlines.

Physics-Informed Digital Twin Can Predict Cerebral Blood Flow and Cerebral Vascular Regulation Mechanisms in Neurocritical Care Patients

This paper introduces CereBRLSIM, a digital twin that predicts cerebral blood flow and CVR mechanisms in neurocritical care patients with higher accuracy than machine learning models.

Depolarization induces calcium-dependent BMP4 release from mouse embryonic palate mesenchyme

The paper shows depolarization induces calcium-dependent BMP4 release from mouse embryonic palate mesenchyme cells, linking ion channels to BMP signaling in craniofacial development.

Heterogeneous Kinetics of Nanobubble Ultrasound Contrast Agent and Angiogenic Signaling in Head and Neck Cancer

The paper analyzes nanobubble ultrasound contrast agent kinetics and angiogenic signaling in head and neck cancer using pixel clustering and proteomics.

Glucokinase activity controls peripherally-located subpopulations of β-cells that lead islet Ca2+ oscillations

This paper uses 3D light-sheet imaging to study β-cell subpopulations and their role in islet Ca2+ oscillations, finding that glucokinase activity patterns leader cells at the periphery.

Synchronized beta cell response to glucose is lost concomitant with loss of islet architecture in Robo deficient islets of Langerhans in vivo

This study shows that loss of Robo1 and Robo2 in beta cells disrupts synchronized calcium oscillations in islets of Langerhans in vivo, indicating that islet architecture is essential for this coordination.