Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment
Youyou Zhang, Mu Xu, Jiao Yuan, Zhongyi Hu, Junjie Jiang, Yanrong Sun, Jie Huang, Yuxin Wang, Bingwei Wang, Jianfeng Shen, Meixiao Long, Yi Fan, Kathleen T. Montone, Janos L. Tanyi, Sarah H. Kim, , Xiaowen Hu
This study identifies PRMT inhibitors as effective combinational therapies with PARP inhibitors to sensitize HR-proficient ovarian and breast cancer cells to treatment.
bioRxiv · May 21, 2024 · PreprintCancer Biology