Author

Yi Fan

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Ágnes HolczbaueriD· 2 shared Ben Z. StangeriD· 2 shared Constantinos KoumenisiD· 2 shared John Alan DiehliD· 2 shared Quoc Thang BuiiD· 2 shared Raghavendra BasavarajaiD· 2 shared Serge Yu. FuchsiD· 2 shared Vladimir S. SpiegelmaniD· 2 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Ágnes HolczbauerORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mono-ADP-ribosylation-driven immunosuppression and cross-resistance to therapy through cancer cell intrinsic and extrinsic mechanisms

Yuchen Sun, Yingying Tang, Vivek T. Singh, Ágnes Holczbauer, Raghavendra Basavaraja, Quoc Thang Bui, Jeong‐Hwa Lee, Runnan Gao, A. Cole Edwards, Wei Guo, John Alan Diehl, Yi Fan, Constantinos Koumenis, Timour Baslan, Ben Z. Stanger, , Serge Yu. Fuchs

This study shows that PARP11-induced MARylation and ubiquitination of MHC-I in cancer cells promotes immunosuppression, tumor growth, and resistance to therapies.

bioRxiv · Jun 3, 2026 · PreprintCancer Biology

Contrast-induced changes in chemical exchange saturation transfer MRI differentiate tumor progression from pseudoprogression

Blake Benyard, Narayan Datt Soni, Anshuman Swain, Nishi Srivastava, Sunil Kumar Khokhar, Akila Ramesh, Junyoung Shin, Dushyant Kumar, Ravinder Reddy, Nadir Yehya, Yi Fan, Mohammed Haris

This paper demonstrates that amine-CEST MRI with Gd-DOTA can distinguish macrophages from cancer cells by detecting Gd-DOTA uptake, aiding in differentiating pseudo-progression from true tumor progression in cancer patients.

bioRxiv · May 23, 2026 · PreprintCancer Biology

SPTBN2 promotes an immunosuppressive tumor microenvironment and cross-resistance to anti-cancer therapies

Quoc Thang Bui, Raghavendra Basavaraja, Mayura R. Dhamdhere, Ágnes Holczbauer, Luca Paruzzo, Puneeth Guruprasad, Michael Scaglione, Yingying Tang, Yu Sun, Daniel P. Beiting, Erik Nash, Hossein Fazelinia, Lynn A. Spruce, Alice Wang, Kai Tan, , Serge Yu. Fuchs

This study identifies SPTBN2 as a regulator of immunosuppressive tumor microenvironment and cross-resistance to therapies, showing its role in suppressing CAR T-cell efficacy.

bioRxiv · Apr 1, 2026 · PreprintCancer Biology

Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

Youyou Zhang, Mu Xu, Jiao Yuan, Zhongyi Hu, Junjie Jiang, Yanrong Sun, Jie Huang, Yuxin Wang, Bingwei Wang, Jianfeng Shen, Meixiao Long, Yi Fan, Kathleen T. Montone, Janos L. Tanyi, Sarah H. Kim, , Xiaowen Hu

This study identifies PRMT inhibitors as effective combinational therapies with PARP inhibitors to sensitize HR-proficient ovarian and breast cancer cells to treatment.

bioRxiv · May 21, 2024 · PreprintCancer Biology