Author

Jianfeng Shen

Every paper listing this name carries an ORCID.

Identified by ORCID

Jianfeng SheniD2 papers · The University of Texas MD Anderson Cancer Center

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Bingwei WangiD· 1 shared C Rao· 1 shared CLIFFORD C. STEPHANiD· 1 shared G Bae· 1 shared G Ira· 1 shared Guang PengiD· 1 shared H-J Hsieh· 1 shared Hengyao NiuiD· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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1 shared paperCancer Biology

Bingwei WangORCID

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2 papers

Recent·Most cited

Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

Youyou Zhang, Mu Xu, Jiao Yuan, Zhongyi Hu, Junjie Jiang, Yanrong Sun, Jie Sheng Huang, Yuxin Wang, Bingwei Wang, Jianfeng Shen, Meixiao Long, Yi Fan, Kathleen T. Montone, Janos Laszlo Tanyi, Sarah H. Kim, , Xiaowen Hu

This study identifies PRMT inhibitors as effective combinational therapies with PARP inhibitors to sensitize HR-proficient ovarian and breast cancer cells to treatment.

eLife · Jul 17, 2024Peer-reviewedCancer Biology

Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells.

Sandeep Kumar, Xiangdong Peng, James M. Daley, Lin Yang, Jianfeng Shen, Nghi Co Nguyen, G Bae, Hengyao Niu, Yang Peng, H-J Hsieh, Lili Wang, C Rao, CLIFFORD C. STEPHAN, Patrick Sung, G Ira, Guang Peng

This study identifies DNA2 nuclease as a therapeutic target for cancer by showing its overexpression in pancreatic cancer and its role in HR repair, with inhibitors reducing tumor growth and HR repair.

Oncogenesis · Apr 17, 2017Peer-reviewedMolecular Biology