Differential regulation of BAX and BAK apoptotic activity revealed by a novel small molecule
Kaiming Li, Yu Q. Yap, Donia M. Moujalled, Fransisca Sumardy, Yelena Khakham, Angela Georgiou, Michelle Jahja, Thomas Eliot Lew, Melanie De Silva, Meng-Xiao Luo, Jianan Gong, Andrew Warwick Roberts, Zheng Yuan, Richard W. Birkinshaw, Peter E. Czabotar, , Guillaume Lessène
This study identifies a small molecule that differentially regulates BAX and BAK apoptotic activity by modulating their interaction with VDAC2, revealing therapeutic potential for overcoming drug resistance in leukemia.
Science Advances · Mar 5, 2025Peer-reviewedCell Biology