Author

Benjamin T. Kile

Garvan Institute of Medical ResearchORCID 0000-0002-8836-8947Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Alpha S. YapiD· 1 shared André L. SamsoniD· 1 shared Andrew H. WeiiD· 1 shared Andrew Warwick RobertsiD· 1 shared Angela Georgiou· 1 shared Aysha Al‐AniiD· 1 shared Britt ChristenseniD· 1 shared Camilla M. ReehorstiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

Alpha S. YapORCID

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2 papers

Recent·Most cited

Sufficient levels of BECLIN1 are required for intestinal epithelial cell homeostasis and protection against unwanted intestinal inflammation

Juliani Juliani, Sharon H. Tran, Tiffany J. Harris, Sarah L. Ellis, Aysha Al‐Ani, Komal M. Patel, Samuel N. Young, Marco Evangelista, David Baloyan, Camilla M. Reehorst, Rebecca Nightingale, Laura J. Jenkins, Peter P. De Cruz, Kinga Duszyc, Benjamin T. Kile, , Erinna F. Lee

This study shows that partial reduction of BECLIN1 in intestinal epithelial cells leads to intestinal defects and increased susceptibility to inflammation, suggesting its importance in maintaining gut health.

bioRxiv · Apr 29, 2025 · PreprintCell Biology

Differential regulation of BAX and BAK apoptotic activity revealed by a novel small molecule

Kaiming Li, Yu Q. Yap, Donia M. Moujalled, Fransisca Sumardy, Yelena Khakham, Angela Georgiou, Michelle Jahja, Thomas Eliot Lew, Melanie De Silva, Meng-Xiao Luo, Jianan Gong, Andrew Warwick Roberts, Zheng Yuan, Richard W. Birkinshaw, Peter E. Czabotar, , Guillaume Lessène

This study identifies a small molecule that differentially regulates BAX and BAK apoptotic activity by modulating their interaction with VDAC2, revealing therapeutic potential for overcoming drug resistance in leukemia.

Science Advances · Mar 5, 2025Peer-reviewedCell Biology