Author

Melanie Wightman

University of Dundee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Dario R. AlessiiD· 2 shared Francesca TonelliiD· 2 shared Alan R. PrescottiD· 1 shared Alexia F. KalogeropulouiD· 1 shared Chloe A HechtiD· 1 shared Ebsy JaimoniD· 1 shared Elena PurlyteiD· 1 shared Emily A. DickieiD· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Dario R. AlessiORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Parkinsons VPS35 mutation induces LRRK2 mediated lysosomal association of RILPL1 and TMEM55B

Prosenjit Pal, Matthew Taylor, Yuko P. Y. Lam, Francesca Tonelli, Chloe A Hecht, Paweł Lis, Raja Sekhar Nirujogi, Toan K. Phung, Wondwossen M Yeshaw, Ebsy Jaimon, Rotimi Yemi Fasimoye, Emily A. Dickie, Melanie Wightman, Thomas Macartney, Suzanne R. Pfeffer, Dario R. Alessi

This study shows that the VPS35[D620N] mutation causes lysosomal dysfunction, activates LRRK2, and promotes the lysosomal association of RILPL1 and TMEM55B through phosphorylation of Rab proteins.

Science Advances · Dec 13, 2023Peer-reviewedNeuroscience

Impact of 100 LRRK2 variants linked to Parkinsons Disease on kinase activity and microtubule binding

Alexia F. Kalogeropulou, Elena Purlyte, Francesca Tonelli, Sven M. Lange, Melanie Wightman, Alan R. Prescott, Shalini Padmanabhan, Esther M. Sammler, Dario R. Alessi

This study evaluates 100 LRRK2 variants linked to Parkinson's disease, identifying those that enhance kinase activity and microtubule binding, and highlights their implications for clinical trials.

Biochemical Journal · Aug 11, 2022Peer-reviewedNeuroscience