Alan R. Prescott

The paper demonstrates that peptides and proteins can self-replicate and form cell-like structures from amino acids in aqueous media without cellular components.

This study identifies the CaMKII-RNMT axis as a mechanism controlling activity-dependent RNA dynamics and neuronal morphogenesis through phosphorylation and degradation of RNMT.

This study identifies HvBDG1 as a gene essential for barley cuticular integrity and wax bloom, showing its interaction with SHINE transcription factors in cuticle development and revealing NUD's broader role beyond grain-specific functions.

This paper designs and evaluates Dyr726, a brain-penetrant multi-kinase inhibitor that targets PI3Kα, receptor tyrosine kinases, and WNT signaling, showing efficacy in preclinical cancer models.

This study compares the proteomes of human induced pluripotent stem cells (hiPSCs) and embryonic stem cells (hESCs), finding quantitative differences in protein expression affecting growth, metabolism, and secreted factors.

This study evaluates 100 LRRK2 variants linked to Parkinson's disease, identifying those that enhance kinase activity and microtubule binding, and highlights their implications for clinical trials.

The paper identifies and characterizes lateral protrusions in neuroepithelial cells, showing they form a latticework regulated by WAVE1 and are involved in neurogenesis.

This study evaluates IL-34 inhibition as a strategy to reduce microglial proliferation in prion disease, showing tissue-selectivity and reduced side effects compared to CSF1R inhibition.