Author

Wondwossen M Yeshaw

Stanford MedicineORCID 0000-0002-3134-3458Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Dario R. AlessiiD· 2 shared Francesca TonelliiD· 2 shared Suzanne R. PfefferiD· 2 shared Aleksander PulykiD· 1 shared Alexander A. ZimprichiD· 1 shared Ayan AdhikariiD· 1 shared Chloe A HechtiD· 1 shared Chloe FlittoniD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

Dario R. AlessiORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

PPM1M, a LRRK2-counteracting, phosphoRab12-preferring phosphatase with potential link to Parkinsons disease

Claire Y Chiang, Neringa Pratuseviciute, Yu‐En Lin, Ayan Adhikari, Wondwossen M Yeshaw, Chloe Flitton, Pemba L. Sherpa, Francesca Tonelli, Irena Rektorová, Timothy Lynch, Joanna S. Siuda, Monika Rudzińska, Aleksander Pulyk, Peter Bauer, Christian Beetz, , Suzanne R. Pfeffer

The paper identifies PPM1M as a phosphatase that reverses LRRK2-mediated Rab phosphorylation and links a rare mutation to Parkinson's disease.

Cell Reports · Jul 20, 2025Peer-reviewedCell Biology

Parkinsons VPS35 mutation induces LRRK2 mediated lysosomal association of RILPL1 and TMEM55B

Prosenjit Pal, Matthew Taylor, Yuko P. Y. Lam, Francesca Tonelli, Chloe A Hecht, Paweł Lis, Raja Sekhar Nirujogi, Toan K. Phung, Wondwossen M Yeshaw, Ebsy Jaimon, Rotimi Yemi Fasimoye, Emily A. Dickie, Melanie Wightman, Thomas Macartney, Suzanne R. Pfeffer, Dario R. Alessi

This study shows that the VPS35[D620N] mutation causes lysosomal dysfunction, activates LRRK2, and promotes the lysosomal association of RILPL1 and TMEM55B through phosphorylation of Rab proteins.

Science Advances · Dec 13, 2023Peer-reviewedNeuroscience