Integrative synaptosome multi-omics reveals disrupted synapse organization and localized cryptic transcripts in C9ORF72-Frontotemporal Dementia
Ashton M Spillman, Eric B. Alsop, Lauren M. Gittings, Krystine Garcia‐Mansfield, Ignazio Stefano Piras, Anna Bonfitto, Melissa N. Martinez, Ritin Sharma, Kim R Preller, Matthew J. Huentelman, Patrick Pirrotte, Kendall R. Van Keuren‐Jensen, Rita Sattler
This study uses multi-omic profiling of synaptosomes to identify molecular changes in C9-FTD, revealing disrupted synaptic pathways and localized cryptic transcripts.
Acta Neuropathologica · Sep 25, 2026Peer-reviewedNeuroscience