Eric B. Alsop

This study uses multi-omic profiling of synaptosomes to identify molecular changes in C9-FTD, revealing disrupted synaptic pathways and localized cryptic transcripts.

This study shows ADAR2-mediated RNA editing promotes TDP-43 nuclear export and alters its RNA binding, contributing to neurodegenerative disease mechanisms.

The paper characterizes microglia-derived extracellular vesicles and non-vesicular particles under inflammatory conditions, showing distinct sialylation patterns and small RNA cargo linked to neuroinflammation.

The paper identifies decreased SNCA expression in Parkinson's Disease blood samples after correcting for immune cell effects, suggesting it as a potential transcriptomic biomarker.

The paper provides a public resource of single nucleus RNA sequencing data and multiscale networks from Alzheimer's disease and non-disease individuals, linking genetic variants to molecular features and revealing novel disease biology.

This study shows that cryopreservation of CSF cells using FBS/DMSO or Recovery media preserves transcriptomic integrity for single-cell analysis, enabling accurate cell type detection and gene expression profiling.

The paper presents a multi-layered molecular dataset from iPSC-derived dopaminergic neurons to model Parkinson's disease genetic risk and provides a data browser for accessing these resources.

This study uses a Drosophila model to investigate TDP-43 proteinopathy in ALS and FTD, identifying shared and circuit-specific molecular targets.

The paper compares transcriptomic responses in skeletal muscle and extracellular vesicles after traditional and high-intensity exercise in young adults, finding more consistent gene responses to traditional exercise and unique microRNA responses to high-intensity training.

The paper identifies TDP-43 proteinopathy's impact on mRNA ribosome association, highlighting Dlp/GPC6 as a novel target in ALS.

The paper analyzes sncRNA-seq data from the PPMI cohort to identify miRNAs associated with Parkinson's disease progression and systemic inflammation.

The paper quantifies technical variability in whole blood transcriptome data from the PPMI study using pooled reference samples and describes the dataset's availability.

This study examines C9orf72 ALS/FTD patient-derived iPSC-microglia mono-cultures, finding they form RNA foci, have reduced C9orf72 protein, and show endosomal-lysosomal dysfunction, but no significant microglial-enriched gene expression differences.