Tumor cell-intrinsic mtDNA instability drives cGAS-dependent temporal remodeling of the melanoma immune microenvironment
Abate Assefa Bashaw, Ashley D. Winters, Yuanjiu Lei, Luiza Ferreira Araujo, Do Gia Tam Vo, Arunachalam Sekar, John F. Bachman, Paige S Graves, Melissa Pineda, Jill Carol Rubinstein, Gerald S. Shadel, Marcus Bosenberg, Laura Ciaccia West, Andrew Phillip West
This study shows that tumor cell-intrinsic mtDNA instability drives temporal changes in the melanoma immune microenvironment through cGAS, affecting immune cell states and therapeutic response.
bioRxiv · Sep 30, 2026 · PreprintImmunology