Comparison of Wild-Type and High-risk PNPLA3 variants in a Human Biomimetic Liver Microphysiology System for Metabolic Dysfunction-associated Steatotic Liver Disease Precision Therapy
Mengying Xia, Mahboubeh Varmazyad, Iris Plá-Palacín, Dillon C. Gavlock, Richard DeBiasio, Gregory M LaRocca, Celeste E. Reese, Rodrigo Machado Florentino, Lanuza A.P. Faccioli, Jacquelyn Ann Brown, Lawrence A. Vernetti, Mark E. Schurdak, Andrew M. Stern, Albert Gough, Jaideep Behari, , Mark T. Miedel
This study uses a human liver microphysiology system to compare the effects of PNPLA3 variants on MASLD progression and drug response.
Frontiers in Cell and Developmental Biology · Sep 11, 2024Peer-reviewedCell Biology