Deriving Schwann Cells from hPSCs Enables Disease Modeling and Drug Discovery for Diabetic Peripheral Neuropathy
Homa Majd, Sadaf Amin, Zaniar Ghazizadeh, Andrius Cesiulis, Edgardo J. Arroyo, Karen L. Lankford, Alireza Majd, Sina Farahvashi, Angeline K Chemel, Mesomachukwu Okoye, Megan D. Scantlen, Jason H. Tchieu, Elizabeth L. Calder, Valerie Le Rouzic, Bradley Shibata, , Faranak Fattahi
This study derives Schwann cells from human pluripotent stem cells to model diabetic peripheral neuropathy and identify a drug candidate that rescues sensory function and prevents myelin damage.
Cell stem cell · May 1, 2023Peer-reviewedDevelopmental Biology