Sadaf Amin

TRAPPC8 Is an Endogenous Brake on UFMylation That Suppresses Tauopathy

This study identifies TRAPPC8 as a brake on UFMylation that suppresses tauopathy by interacting with UBA5, showing its therapeutic potential in Alzheimer's disease.

cGAS inhibition delays TDP-43-driven ALS Pathogenesis

This study identifies cGAS as a key mediator of TDP-43 pathology in ALS and shows that its inhibition reduces RNA splicing defects and neurodegeneration.

cGAS-mediated IFN-I signaling contributes to disease progression in drug-refractory epilepsy

This study identifies cGAS-mediated IFN-I signaling as a driver of disease progression in drug-refractory epilepsy, showing that targeting cGAS reduces epileptic phenotypes and inflammation.

DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity

This study shows that DAP12 deficiency reduces tau-induced inflammation and myelin loss in mice, despite increased tau pathology, by altering microglia-oligodendrocyte interactions.

Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

This study combines APOE4 and TREM2R47H in female tauopathy mice to identify pathways activated by AD risk factors, finding cGAS-STING signaling and microglial senescence as potential drivers.

Deriving Schwann Cells from hPSCs Enables Disease Modeling and Drug Discovery for Diabetic Peripheral Neuropathy

This study derives Schwann cells from human pluripotent stem cells to model diabetic peripheral neuropathy and identify a drug candidate that rescues sensory function and prevents myelin damage.