Abolfazl Arab

This paper identifies BisRoc, a dimeric rocaglate ligand that suppresses translation more potently and specifically than monomeric RocA by promoting multivalent eIF4A-RNA assembly.

The paper introduces multiAsCas12a, an engineered CRISPR-Cas12a variant enabling higher-order combinatorial chromatin perturbations, and demonstrates its use in discovering new enhancer elements and dissecting cis-regulatory element functions.

This study derives Schwann cells from human pluripotent stem cells to model diabetic peripheral neuropathy and identify a drug candidate that rescues sensory function and prevents myelin damage.

The paper develops a data integrator to uncover synthetic lethality, sex disparity, and immunotherapy targets in cancer by combining public and custom datasets.