Targeting folate-dependent purine synthesis sensitizes melanoma cells to immune attack through suppressing glycolysis
D J Li, Miaomiao Hou, Shoubao Wang, Xinyuan Wan, Haiqiong Wang, Yun-Hee Han, Xi Liu, Chaojiang Cheng, Jian Zhang, X Hu
This study shows that inhibiting folate-dependent purine synthesis in melanoma cells enhances their sensitivity to T cell killing by suppressing glycolysis and reducing PD-L1 stability.
bioRxiv · Jul 7, 2026 · PreprintCancer Biology