Chaojiang Cheng

Shared and distinct immunometabolic states link to divergent pathology in cutaneous mycobacterial infections

This study identifies shared and distinct innate immune programs in cutaneous mycobacterial infections and links them to divergent pathological outcomes through metabolic interactions.

Targeting folate-dependent purine synthesis sensitizes melanoma cells to immune attack through suppressing glycolysis

This study shows that inhibiting folate-dependent purine synthesis in melanoma cells enhances their sensitivity to T cell killing by suppressing glycolysis and reducing PD-L1 stability.