Xi Liu

Targeting folate-dependent purine synthesis sensitizes melanoma cells to immune attack through suppressing glycolysis

This study shows that inhibiting folate-dependent purine synthesis in melanoma cells enhances their sensitivity to T cell killing by suppressing glycolysis and reducing PD-L1 stability.

Structure of the E3 ligase CRL2-ZYG11B with substrates reveals the molecular basis for N-degron recognition and ubiquitination

The paper presents Cryo-EM structures of the CRL2-ZYG11B complex with substrates, revealing how ZYG11B recognizes and ubiquitinates Gly/N-degrons to activate the NLRP1 inflammasome.

NFIC-mediated CaSR endocytosis defines a hyperactive TOMM20highCHGAhigh oxyphil cell state as a pathological driver of autonomous secondary hyperparathyroidism

This study identifies an NFIC-driven endo-lysosomal pathway causing CaSR downregulation in SHPT and shows HCQ can reverse this process.

Evolutionary genomics of the emergence of brown algae as key components of coastal ecosystems

This study analyzes 60 brown algal genomes to identify genomic innovations and evolutionary patterns that enabled their adaptation to coastal ecosystems.

The genome of Ectocarpus subulatus - a highly stress-tolerant brown alga

This paper presents the genome and metabolic network of Ectocarpus subulatus, a stress-tolerant brown alga, and identifies features contributing to its stress tolerance.

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

Affinity-purification mass spectrometry of 26 SARS-CoV-2 proteins in HEK293T cells yields 332 high-confidence host interactions and 67 druggable human proteins with known compounds.