D J Li

The paper introduces gecco, a gene-specific normalization method for bulk RNA-seq that reduces library size bias while preserving biological signal, improving differential expression and pathway analysis.

This study shows that inhibiting folate-dependent purine synthesis in melanoma cells enhances their sensitivity to T cell killing by suppressing glycolysis and reducing PD-L1 stability.

This paper develops GPC3-targeted CAR T cells resistant to immunosuppressive drugs and with reduced alloreactivity, showing efficacy in preclinical models and feasibility for clinical use post-liver transplantation.

This study identifies distinct defense strategies used by Acinetobacter to persist in polymicrobial infections, including T6SS effectors, polysaccharide capsules, and plasmid-mediated suppression of kin.