Tumor control of lysosomal acidification promotes lipoprotein assimilationand ferroptosis resistance
Renfei Wu, Sheng‐Chieh Hsu, Lingjie Sang, Miaomiao Yu, Yoon Jung Kim, Mangyu Choe, Caroline Hauer, Ling Cai, Ariella B. Hanker, Isaac S. Chan, Hijai R. Shin, Javier García‐Bermúdez
This study identifies ZNF217 as a driver of tumor lysosomal function and ferroptosis resistance by maintaining lysosomal acidification and lipoprotein assimilation.
bioRxiv · Aug 26, 2026 · PreprintCancer Biology