Ling Cai

MCT1 activity defines an aggressive metabolic phenotype and therapeutic target in non-small cell lung cancer

This study shows that MCT1-mediated lactate uptake sustains nucleotide homeostasis in NSCLC, and its inhibition enhances chemotherapy efficacy by exposing a metabolic vulnerability.

Tumor control of lysosomal acidification promotes lipoprotein assimilationand ferroptosis resistance

This study identifies ZNF217 as a driver of tumor lysosomal function and ferroptosis resistance by maintaining lysosomal acidification and lipoprotein assimilation.

The liver compensates for zonal loss of glucose 6-phosphatase to prevent glycogen storage disease

This study shows that localized loss of G6pc1 in liver zones causes local glycogen accumulation but not systemic disease, highlighting organ-wide compensation for metabolic homeostasis.

Spatial Topology Reveals Biologically Distinct Recurrent Motifs in Colorectal Cancer

The paper introduces STORM, a method to identify recurrent spatial motifs in colorectal cancer without cell-type labels, finding a fibroblast barrier linked to immune exclusion and prognosis.

Heterozygous MMACHC burden variants are associated with higher circulating vitamin B12 in the All of Us Research Program

The paper identifies higher circulating vitamin B12 in heterozygous MMACHC carriers in the All of Us Research Program, suggesting impaired cellular cobalamin handling rather than improved function.

UFMylation of Pyruvate Dehydrogenase Regulates Mitochondrial Metabolism

This study identifies UFMylation of PDH as a regulator of mitochondrial metabolism, showing it enhances pyruvate oxidation and TCA cycle activity.

L-2-hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression

This study shows that L-2HG accumulation due to L2HGDH deficiency impairs neuronal differentiation by epigenetically activating MYC, leading to stem cell self-renewal and reduced neuron formation.

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT

This study identifies NUDT5 as a regulator of purine metabolism and thiopurine sensitivity by interacting with PPAT, independent of its known enzymatic activity.

Glycosaminoglycan-mediated lipoprotein uptake protects cancer cells from ferroptosis

This study identifies glycosaminoglycan-mediated lipoprotein uptake as a mechanism by which cancer cells resist ferroptosis and lipid oxidative stress.

Attention Guided Mechanism Interpretable Drug-Gene Interaction (MIDI) Modeling for Cancer Drug Response Prediction and Target Effect Explanation

This paper introduces MIDI, a model that predicts cancer drug response and explains drug-target interactions using an attention mechanism, outperforming existing methods in prediction and interpretability.

A Lung Cancer Mouse Model Database

The paper establishes a database of lung cancer mouse models to improve data comparison and translational relevance by aligning mouse mutations with human lung cancer mutations.

An interactive web application for exploring human plasma and fibroblast metabolomics data from patients with inborn errors of metabolism

The paper introduces a web application for exploring metabolomics data from plasma and fibroblasts of patients with inborn errors of metabolism, enabling analysis of metabolic deviations and relationships.

A comparative study of neuroendocrine heterogeneity in SCLC and NBL

This study compares neuroendocrine (NE) features in SCLC and NBL, finding similar molecular profiles and shared therapeutic responses but no significant survival association with NE scores.

Computational staining of pathology images to study tumor microenvironment in lung cancer

The paper develops a deep learning tool to analyze pathology images and identify TME features predictive of survival in lung cancer.