BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability
Michael A. Longo, Syed Moiz Ahmed, Yue Chen, Chi-Lin Tsai, Sarita Namjoshi, Runze Shen, Zamal Ahmed, Xiaoyan Wang, Rajika L. Perera, Andy Arvai, Miyoung Lee, Li Ren Kong, Wilfried Engl, Woei Shyuan Ng, Ziqing Zhao, , Katharina Schlacher
This study reveals how the BRCA2 C-terminal domain reshapes RAD51 dimers to bind B-DNA, promoting replication fork stability over homology-directed repair.
Molecular Cell · Jun 1, 2025Peer-reviewedMolecular Biology