Ashok R. Venkitaraman

KRAS G12 mutant alleles differentially control glutamine metabolism via FOXO1

This study identifies how different KRAS G12 alleles alter glutamine metabolism and nitrogen recycling through FOXO1 regulation in colorectal cancer cells, revealing potential therapeutic targets.

BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability

This study reveals how the BRCA2 C-terminal domain reshapes RAD51 dimers to bind B-DNA, promoting replication fork stability over homology-directed repair.

Rewiring of chromatin loops in adipogenesis reveals targets for obesity and diabetes intervention

The paper identifies chromatin loop rewiring in adipogenesis and discovers novel regulators and gene-trait associations relevant to obesity and diabetes.

A systems view of spliceosomal assembly and branchpoints with iCLIP

The paper uses spliceosome iCLIP to map human spliceosome engagement with snRNAs and pre-mRNAs, identifying over 50,000 branchpoints and their associated splicing factor binding patterns.

Multiplexed biochemical imaging reveals caspase activation patterns underlying single cell fate

This study uses multiplexed biochemical imaging to reveal caspase activation patterns that determine single-cell fate in response to cisplatin, showing non-genetic heterogeneity in cell death mechanisms.

Checkpoint non-fidelity induces a complex landscape of lineage fitness after DNA damage

The paper shows that transient DNA damage with checkpoint non-fidelity leads to varied lineage fitness outcomes in descendant cells, promoting persistence in mutagenic environments.