Author

Wilfried Engl

National University of Singapore

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:imaging· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:microscopy & imaging analysis· 1 Research Focus:spatial domain detection· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Ziqing Winston ZHAOiD· 3 shared Woei Shyuan NgiD· 2 shared Andy ArvaiiD· 1 shared Ashok R. VenkitaramaniD· 1 shared Chi-Lin TsaiiD· 1 shared John A. TaineriD· 1 shared Katharina SchlacheriD· 1 shared Li Ren KongiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiophysics

Ziqing Winston ZHAOORCID

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3 papers

Recent·Most cited

Senescence-induced Spatio-temporal Re-organization of the Nuclear Lamina Dynamic Landscape at Single-molecule Level in Live Human RPE Cells

Xuan Kuo, Wilfried Engl, Pakorn Kanchanawong, Ziqing Winston ZHAO

This study investigates how senescence alters the spatio-temporal dynamics of the nuclear lamina at the single-molecule level in human RPE cells.

bioRxiv · Oct 9, 2026 · PreprintBiophysics

Nucleolar Condensation Orchestrates rRNA-dependent Mobility and Spatiotemporally Enriches rDNA-binding of Human Chromatin Remodeler BRG1

Woei Shyuan Ng, Wilfried Engl, Ziqing Zhao

This study shows that BRG1 forms nucleolar condensates that regulate rDNA binding and rRNA-dependent mobility, linking chromatin remodeling to nucleolar architecture.

bioRxiv · Apr 4, 2026 · PreprintBiophysics

BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability

Michael A. Longo, Syed Moiz Ahmed, Yue Chen, Chi-Lin Tsai, Sarita Namjoshi, Runze Shen, Zamal Ahmed, Xiaoyan Wang, Rajika L. Perera, Andy Arvai, Miyoung Lee, Li Ren Kong, Wilfried Engl, Woei Shyuan Ng, Ziqing Zhao, , Katharina Schlacher

This study reveals how the BRCA2 C-terminal domain reshapes RAD51 dimers to bind B-DNA, promoting replication fork stability over homology-directed repair.

Molecular Cell · Jun 1, 2025Peer-reviewedMolecular Biology