Synergistic MAPT mutations as a platform to uncover modifiers of tau pathogenesis
Miles R. Bryan, Michael Almeida, Kyle Pellegrino, Carli K. Opland, Ethan Paulakonis, Jake McGillion-Moore, Hanna Trzeciakiewicz, Diamond P. King, Tian Xu, Jui‐Heng Tseng, Jonathan Cummings Schisler, Nicholas G Brown, Ben A. Bahr, Todd J Cohen
This study uses synergistic MAPT mutations to create a model for tau aggregation, identifying Hsp70 as a key driver and showing its impact on neuronal function.
bioRxiv · Feb 7, 2025 · PreprintNeuroscience