Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming
Yuancheng Ryan Lu, Anitha Krishnan, Benedikt Brommer, Xiao Tian, Margarita V. Meer, Daniel L. Vera, Chen Wang, Qiurui Zeng, Doudou Yu, Michael S. Bonkowski, Jae-Hyun Yang, Emma M. Hoffmann, Songlin Zhou, Ekaterina D. Korobkina, Noah Davidsohn, , David A. Sinclair
This paper demonstrates that epigenetic reprogramming using OSK genes can reverse age-related and injury-induced vision loss in mice by resetting DNA methylation patterns and promoting axon regeneration.
bioRxiv · Jul 31, 2019 · PreprintMolecular Biology