Yuancheng Ryan Lu

A genome-scale ORF screen for resilience factors that protect the RPE and restore vision in aged mice

The paper identifies resilience factors in aged mice using a genome-scale ORF screen, finding NKX2-5 variants that restore vision and reduce frailty.

Atlas of Lysosomal Aging Reveals a Molecular Clock of Storage Disorder-Associated Metabolites

The paper constructs a multi-tissue lysosomal metabolite atlas in mice, revealing age-related accumulation of glycerophosphodiesters and cystine, linked to lysosomal storage disorders, and shows caloric restriction mitigates these changes in some tissues.

Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision

OSK factors rejuvenate aged RPE cells by activating a Tet2-independent oxidative resilience pathway through GSTA4, restoring vision and reversing age-related degeneration.

Cell-type-specific transposable element demethylation and TAD remodeling in the aging mouse brain

The paper maps epigenetic and spatial transcriptomic changes in aging mouse brain using single-cell multi-omic data and develops deep-learning models to predict age-related gene expression changes.

Cellular rejuvenation protects neurons from inflammation mediated cell death.

This study identifies a senescent-like phenotype in neurons under inflammation and shows that rejuvenation improves survival in an MS model.

Spateo: multidimensional spatiotemporal modeling of single-cell spatial transcriptomics

Spateo provides a framework for spatiotemporal modeling of single-cell spatial transcriptomics data to study cell-cell interactions and organ development in 3D space.

Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming

This paper demonstrates that epigenetic reprogramming using OSK genes can reverse age-related and injury-induced vision loss in mice by resetting DNA methylation patterns and promoting axon regeneration.