Pericytes and Wnt signaling induce functional blood-brain barrier phenotype in human iPSC-based model
Henrique Nogueira Pinto, N. Kok, Philipp Christoph Hauger, Manon Karsten-van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline Paulina Nugteren‐Boogaard, Peter Lodewijk Hordijk, Stephanie D. Beekhuis-Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries
This paper develops a human iPSC-based model of the blood-brain barrier by co-culturing endothelial cells with pericytes and activating Wnt/β-catenin signaling, resulting in cells with BBB-like properties and gene expression patterns.
Small Methods · Jan 28, 2026Peer-reviewedBioengineering