Peter Lodewijk Hordijk

Marfan Patient iPSC-Derived Endothelial Cells Carrying FBN1 Variants Reveal Endothelial Dysfunction

This study uses iPSC-derived endothelial cells from Marfan syndrome patients to show impaired inflammatory resolution and endothelial dysfunction linked to FBN1 variants.

Pericytes and Wnt signaling induce functional blood-brain barrier phenotype in human iPSC-based model

This paper develops a human iPSC-based model of the blood-brain barrier by co-culturing endothelial cells with pericytes and activating Wnt/β-catenin signaling, resulting in cells with BBB-like properties and gene expression patterns.

Vessel-on-Chip Model Of The Microcirculation In Abdominal Aortic Aneurysms

This study develops a patient-specific vessel-on-chip model of abdominal aortic aneurysms, showing preserved pathological features and pro-inflammatory responses in vitro.

NUAK1 regulates contraction in vascular smooth muscle cells derived from abdominal aortic aneurysm patients

This study identifies NUAK1 as a regulator of vascular smooth muscle cell contraction in abdominal aortic aneurysm patients, showing its role in modulating MYPT1 activity and contraction-related proteins.

Rapid proteostasis controls monolayer integrity of quiescent endothelium

The paper shows that rapid proteostasis is essential for maintaining monolayer integrity in quiescent endothelial cells by regulating protein turnover that affects cell-cell contact.