Michael J. Doolittle

Prenatal exposure to valproic acid reduces synaptic δ-catenin levels and disrupts ultrasonic vocalization in neonates

This study shows that prenatal valproic acid exposure reduces δ-catenin levels and disrupts synaptic function and ultrasonic vocalization in mice, linking these changes to autism spectrum disorder.

HIV and FIV glycoproteins increase cellular tau pathology via cGMP-dependent kinase II activation

This study shows HIV and FIV glycoproteins increase tau pathology in neurons through cGMP-dependent kinase II activation, suggesting a link between HIV infection and accelerated Alzheimer's-like pathology.

Loss of cGMP-dependent protein kinase II alters ultrasonic vocalizations in mice, a model for speech impairment in human microdeletion 4q21 syndrome

This study shows that cGKII knockout mice exhibit altered ultrasonic vocalizations and hypothalamic neuron activation, suggesting they model speech impairment in human 4q21 microdeletion syndrome.