Hadassah Mendez-Vazquez

This paper identifies a novel mechanism by which manganese disrupts mitochondrial transcriptome processing, leading to dsRNA accumulation and neuroinflammation through MDA5 activation.

The paper identifies haploinsufficient genes MRPL40 and SLC25A1 in the 22q11.2 locus and shows their genetic interactions contribute to cardiac and brain phenotypes in mice.

This study shows that prenatal valproic acid exposure reduces δ-catenin levels and disrupts synaptic function and ultrasonic vocalization in mice, linking these changes to autism spectrum disorder.

This study shows that ketamine's rapid antidepressant effects in mice are mediated by increased expression of Ca2+-permeable AMPA receptors in the hippocampus through reduced calcineurin activity.

This paper investigates how the G34S mutation in δ-catenin causes loss of function leading to social dysfunction in ASD by altering glutamatergic activity and GSK3β-mediated degradation.