Seonil Kim

Co-activation of selective nicotinic acetylcholine receptor subtypes is required for neuroprotection against Alzheimers disease

The paper identifies that co-activation of 7- and 4β2-nAChRs in specific hippocampal interneurons is necessary to reverse AD-related hyperexcitability and memory loss.

δ-catenin haploinsufficiency is sufficient to alter behaviors and glutamatergic synapses in mice

This study shows that δ-catenin haploinsufficiency in mice disrupts social behavior and fear learning, and alters glutamatergic synaptic activity.

American ginseng (Panax quinquefolius L.) extracts (G1899) reverse stress-induced behavioral abnormalities in mice

This study shows that American ginseng extract G1899 reverses both acute and chronic stress-induced behavioral abnormalities in mice by reducing glutamatergic activity and corticosterone levels.

Ketamine reverses chronic stress-induced behavioral changes via Ca2+-permeable AMPA receptors in mice

This study shows low-dose ketamine reverses chronic stress-induced behavioral issues in mice by activating Ca2+-permeable AMPA receptors in the hippocampus.

Prenatal exposure to valproic acid reduces synaptic δ-catenin levels and disrupts ultrasonic vocalization in neonates

This study shows that prenatal valproic acid exposure reduces δ-catenin levels and disrupts synaptic function and ultrasonic vocalization in mice, linking these changes to autism spectrum disorder.

Ketamines rapid antidepressant effects are mediated by Ca2+ - permeable AMPA receptors in the hippocampus

This study shows that ketamine's rapid antidepressant effects in mice are mediated by increased expression of Ca2+-permeable AMPA receptors in the hippocampus through reduced calcineurin activity.

The autism-associated loss of δ-catenin functions disrupts social behaviors

This paper investigates how the G34S mutation in δ-catenin causes loss of function leading to social dysfunction in ASD by altering glutamatergic activity and GSK3β-mediated degradation.

HIV and FIV glycoproteins increase cellular tau pathology via cGMP-dependent kinase II activation

This study shows HIV and FIV glycoproteins increase tau pathology in neurons through cGMP-dependent kinase II activation, suggesting a link between HIV infection and accelerated Alzheimer's-like pathology.

Phosphorylation of AMPA receptor subunit GluA1 regulates clathrin-mediated receptor endocytosis

This study shows that phosphorylation of GluA1 at S845 reduces AP2 binding, decreasing AMPAR endocytosis and increasing surface expression during synaptic plasticity.

Loss of cGMP-dependent protein kinase II alters ultrasonic vocalizations in mice, a model for speech impairment in human microdeletion 4q21 syndrome

This study shows that cGKII knockout mice exhibit altered ultrasonic vocalizations and hypothalamic neuron activation, suggesting they model speech impairment in human 4q21 microdeletion syndrome.

Selective co-activation of α7- and α4β2-nicotinic acetylcholine receptors reverses beta-amyloid-induced synaptic dysfunction