Author

Michael S. Bosmeny

Wake Forest University Health Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:CRISPR screen· 2 Research Focus:database / resource· 2 Organism:virus· 2 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Adrian A. Pater· 5 shared Keith T. GagnoniD· 5 shared Ramadevi Chilamkurthy· 4 shared Christopher L. BarkauiD· 3 shared Mansi Parasrampuria· 3 shared Seth B. Eddington· 3 shared Abadat O. Yinusa· 2 shared Adam A. White· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersGenomics

Adrian A. Pater

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Chemical control of 2'-hydroxyl-dependent Cas9 target engagement enables CRISPR RNA ribose replacement

Adrian A. Pater, Halle M. Barber, Sruthi Sudhakar, Ramadevi Chilamkurthy, Sunit Kumar Jana, Mansi Parasrampuria, Michael S. Bosmeny, Jacob A Graczyk-Marrs, Seth B. Eddington, Cole A Blazier, Leonora Abdullahu, Elise Malek-Adamian, Christopher L. Barkau, Daniel O’Reilly, Sergey Korolev, , Keith T. Gagnon

This study identifies the role of 2'-hydroxyl groups in crRNA for Cas9 DNA binding and develops chemically stabilized crRNAs with enhanced nuclease resistance and editing efficiency.

bioRxiv · Jan 26, 2026 · PreprintBiochemistry

A guide RNA repeat checkpoint steers CRISPR-Cas9 catalysis

Ramadevi Chilamkurthy, Sruthi Sudhakar, Adrian A. Pater, Michael S. Bosmeny, Francis Stabile, Adam Katolik, S. Harikrishna, Rolf Turk, Masad J. Damha, Sabrina Leslie, Sergey Korolev, P.I. Pradeepkumar, Keith T. Gagnon

The paper identifies a guide RNA repeat checkpoint that regulates CRISPR-Cas9 catalysis and proposes guide repeat-truncated sgRNAs to improve editing specificity.

bioRxiv · Dec 2, 2025 · PreprintBiochemistry

An HIV-1 Reference Epitranscriptome

Michael S. Bosmeny, Adrian A. Pater, Li Zhang, Lydia Larkai, Beverly E. Sha, Zidi Lyu, Masad José Damha, João I. Mamede, Keith T. Gagnon

The paper establishes a reference HIV-1 epitranscriptome by sequencing the NL4-3 HIV-1 genome and identifying RNA modifications, revealing their stability under treatment and conservation in patients.

bioRxiv · Jan 30, 2025 · PreprintGenomics

High Throughput Nanopore Sequencing of SARS-CoV-2 Viral Genomes from Patient Samples

Adrian A. Pater, Michael S. Bosmeny, Mansi Parasrampuria, Seth B. Eddington, Katy N. Ovington, Adam A. White, Christopher L. Barkau, Paige E. Metz, Rourke J. Sylvain, Ramadevi Chilamkurthy, Abadat O. Yinusa, Scott W. Benzinger, Madison M. Hebert, Keith T. Gagnon

The paper provides protocols for high throughput sequencing of SARS-CoV-2 genomes using MinION and ARTIC primers, with applicable steps for other platforms.

Journal of Biological Methods · Sep 27, 2021Peer-reviewedGenomics

Emergence and Evolution of a Prevalent New SARS-CoV-2 Variant in the United States

Adrian A. Pater, Michael S. Bosmeny, Christopher L. Barkau, Katy N. Ovington, Ramadevi Chilamkurthy, Mansi Parasrampuria, Seth B. Eddington, Abadat O. Yinusa, Adam A. White, Paige E. Metz, Rourke J. Sylvain, Madison M. Hebert, Scott W. Benzinger, Koushik Sinha, Keith T. Gagnon

The paper identifies a new SARS-CoV-2 variant, 20C-US, that emerged in the U.S. in 2020 and became prevalent during the third pandemic wave.

bioRxiv · Jan 11, 2021 · PreprintGenomics