Deep mutational scanning of influenza A virus NEP reveals pleiotropic mutations in its N-terminal domain
Qi Wen Teo, Yiquan Wang, Huibin Lv, Michael S. Oade, Kevin J. Mao, Timothy J.C. Tan, Yang Wei Huan, Joel Rivera-Cardona, Evan K. Shao, Danbi Choi, Chaoyang Wang, Zahra Tavakoli Dargani, Christopher B. Brooke, Aartjan J.W. te Velthuis, Nicholas C. Wu
This study uses deep mutational scanning to analyze the functional impact of NEP mutations in influenza A virus, revealing pleiotropic effects on viral replication and host adaptation.
Cell Reports · Jan 1, 2025Peer-reviewedCell Biology