Kevin J. Mao

Mutational fitness landscapes of diverse human influenza H1N1 neuraminidases

This study quantifies the replication fitness effects of mutations in diverse H1N1 influenza neuraminidases, revealing strain-dependent effects and epistasis patterns.

TRIM21 is a molecular rheostat for influenza A virus replication

This study shows TRIM21 acts as a molecular rheostat regulating influenza A virus replication by modulating ubiquitination and innate immune signaling, with PRKDC as a compensatory antiviral factor when TRIM21 is absent.

Evolution of antibody cross-reactivity to influenza H5N1 neuraminidase from an N2-specific germline

This study identifies an antibody that cross-reacts with H5N1 and H3N2 neuraminidases and shows how somatic hypermutation enables this cross-reactivity.

Deep mutational scanning of influenza A virus NEP reveals pleiotropic mutations in its N-terminal domain

This study uses deep mutational scanning to analyze the functional impact of NEP mutations in influenza A virus, revealing pleiotropic effects on viral replication and host adaptation.

Differential antigenic imprinting effects between influenza H1N1 hemagglutinin and neuraminidase in a mouse model

This study examines how immune history affects antibody responses to influenza H1N1 hemagglutinin and neuraminidase in mice, finding that HA responses are more restricted by prior infection than NA responses.

Stringent and complex sequence constraints of an IGHV1-69 broadly neutralizing antibody to influenza HA stem

This study identifies sequence constraints for IGHV1-69 antibodies targeting influenza HA stem, showing light chain and CDR H3 sequences coordinate HA stem specificity.