5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer
Fabio Puddu, Annelie Johansson, Aurélie Modat, Jamie Scotcher, Riccha Sethi, Shirong Yu, Nick Harding, Mark S. Hill, Ermira Lleshi, Casper K. Lumby, Jean Teyssandier, Michael Wilson, Robert Crawford, Tom Charlesworth, Páidí Creed, , Robert J. Osborne
This study shows that combining 5mC and 5hmC measurements improves early CRC detection accuracy compared to conflated markers.
Communications Medicine · Jan 20, 2026Peer-reviewedCancer Biology