Author

Aurélie Modat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Robert CrawfordiD· 3 shared Anjana RaoiD· 2 shared Ermira Lleshi· 2 shared Fabio PudduiD· 2 shared Geoffrey J. FaulkneriD· 2 shared Isaac F. López-MoyadoiD· 2 shared J. Carlos AngeliD· 2 shared Jamie ScotcheriD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Robert CrawfordORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Flanking DNA sequences determine DNA methylation maintenance in proliferation, cancer and aging

Isaac F. López-Moyado, Lot Hernández-Espinosa, J. Carlos Angel, Aurélie Modat, Ermira Lleshi, Robert Crawford, Geoffrey J. Faulkner, Anjana Rao

The paper identifies DNA hexanucleotide sequences that determine DNA methylation maintenance across cell divisions, revealing their role in biological age and cancer progression.

bioRxiv · Apr 11, 2026 · PreprintGenomics

5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer

Fabio Puddu, Annelie Johansson, Aurélie Modat, Jamie Scotcher, Riccha Sethi, Shirong Yu, Nick Harding, Mark S. Hill, Ermira Lleshi, Casper K. Lumby, Jean Teyssandier, Michael Wilson, Robert Crawford, Tom Charlesworth, Páidí Creed, , Robert J. Osborne

This study shows that combining 5mC and 5hmC measurements improves early CRC detection accuracy compared to conflated markers.

Communications Medicine · Jan 20, 2026Peer-reviewedCancer Biology

OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide

Hugo Sepúlveda, Xiang Li, Leo J. Arteaga-Vazquez, Isaac F. López-Moyado, Melina Brunelli, Lot Hernández-Espinosa, Xiaojing Yue, J. Carlos Angel, Caitlin Brown, Zhen Dong, Natasha Jansz, Fabio Puddu, Aurélie Modat, Jamie Scotcher, Páidí Creed, , Anjana Rao

This study shows that OGT inhibits TET activity, preventing DNA demethylation and transposable element expression in heterochromatin.

Nature Structural & Molecular Biology · Mar 28, 2025Peer-reviewedMolecular Biology