Author

Ermira Lleshi

Wellcome Sanger Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:differential expression· 2 Organism:human· 2 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Aurélie Modat· 2 shared Robert CrawfordiD· 2 shared Aldo Segura‐CabreraiD· 1 shared Alexandra BeckiD· 1 shared Andrew R. LeachiD· 1 shared Andrew S. Barthorpe· 1 shared Anjana RaoiD· 1 shared Annelie JohanssoniD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersGenomics

Aurélie Modat

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Flanking DNA sequences determine DNA methylation maintenance in proliferation, cancer and aging

Isaac F. López-Moyado, Lot Hernández-Espinosa, J. Carlos Angel, Aurélie Modat, Ermira Lleshi, Robert Crawford, Geoffrey J. Faulkner, Anjana Rao

The paper identifies DNA hexanucleotide sequences that determine DNA methylation maintenance across cell divisions, revealing their role in biological age and cancer progression.

bioRxiv · Apr 11, 2026 · PreprintGenomics

5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer

Fabio Puddu, Annelie Johansson, Aurélie Modat, Jamie Scotcher, Riccha Sethi, Shirong Yu, Nick Harding, Mark S. Hill, Ermira Lleshi, Casper K. Lumby, Jean Teyssandier, Michael Wilson, Robert Crawford, Tom Charlesworth, Páidí Creed, , Robert J. Osborne

This study shows that combining 5mC and 5hmC measurements improves early CRC detection accuracy compared to conflated markers.

Communications Medicine · Jan 20, 2026Peer-reviewedCancer Biology

Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens

Emanuel Gonçalves, Aldo Segura‐Cabrera, Clare Pacini, Gabriele Picco, Fiona M. Behan, Patricia Jaaks, Elizabeth A. Coker, Donny van der Meer, Andrew S. Barthorpe, Howard W. Lightfoot, Tatiana Mironenko, Alexandra Beck, Laura Richardson, Wanjuan Yang, Ermira Lleshi, , Mathew J. Garnett

This study integrates drug sensitivity data with CRISPR screens to identify drug mechanisms and biomarkers for cancer therapy.

Molecular Systems Biology · Jul 1, 2020Peer-reviewedSystems Biology