Author

Shirong Yu

Cardiff UniversityORCID 0000-0002-0884-9987Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Genomics· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:variant calling· 2

Frequent Co-Authors

Casper K. LumbyiD· 2 shared Mark Bennett· 2 shared Matthew Leadbitter· 2 shared Páidí Creed· 2 shared Patrick van EijkiD· 2 shared Shankar BalasubramanianiD· 2 shared Simon Huw ReediD· 2 shared Tom CharlesworthiD· 2 shared

Activity by Year

2016-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Casper K. LumbyORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer

Fabio Puddu, Annelie Johansson, Aurélie Modat, Jamie Scotcher, Riccha Sethi, Shirong Yu, Nick Harding, Mark S. Hill, Ermira Lleshi, Casper K. Lumby, Jean Teyssandier, Michael Wilson, Robert Crawford, Tom Charlesworth, Páidí Creed, , Robert J. Osborne

This study shows that combining 5mC and 5hmC measurements improves early CRC detection accuracy compared to conflated markers.

Communications Medicine · Jan 20, 2026Peer-reviewedCancer Biology

Accurate simultaneous sequencing of genetic and epigenetic bases in DNA

Jens Füllgrabe, Walraj S. Gosal, Páidí Creed, Sidong Liu, Casper K. Lumby, David J. Morley, Tobias W. B. Ost, Albert J. Vilella, Shirong Yu, Helen Bignell, Philippa Burns, Tom Charlesworth, Beiyuan Fu, Howerd Fordham, Nicholas J. Harding, , Shankar Balasubramanian

This paper introduces a method to simultaneously sequence genetic and epigenetic bases in DNA with single-base resolution, demonstrating accuracy and versatility in human genomic and cell-free DNA samples.

Nature Biotechnology · Feb 6, 2023Peer-reviewedGenomics

Nucleosome remodelling at origins of Global Genome-Nucleotide Excision Repair occurs at the boundaries of higher-order chromatin structure

Patrick van Eijk, Shuvro Prokash Nandi, Shirong Yu, Mark Bennett, Matthew Leadbitter, Yumin Teng, Simon Huw Reed

The paper identifies chromatin domains and shows how GG-NER initiates repair by remodeling nucleosomes at gene promoter boundaries.

Genome Research · Jan 1, 2019Peer-reviewedGenomics

Global Genome Nucleotide Excision Repair is Organised into Domains Promoting Efficient DNA Repair in Chromatin

Shirong Yu, Katie Ellen Evans, Patrick van Eijk, Mark Bennett, Richard M Webster, Matthew Leadbitter, Yumin Teng, Raymond Waters, Stephen Philip P Jackson, Simon Huw Reed

The paper examines how DNA repair rates vary across the genome in budding yeast and shows that GG-NER is organized into chromatin domains that promote efficient repair.

bioRxiv · Apr 28, 2016Genomics