Author

Irina V. Lebedeva

Columbia University Irving Medical CenterORCID 0000-0002-1693-9392Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Abigail TayloriD· 1 shared Anuli Anyanwu‐Ofili· 1 shared Clarisse Kayembe· 1 shared Daniel C. ChoiiD· 1 shared David B. GoldsteiniD· 1 shared Elisabeth K. Nyakatura· 1 shared Franco Castillo TokumoriiD· 1 shared Giorgio InghiramiiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Abigail TaylorORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintFeb 11, 2026

CAR-T Targeting of Mutant Calreticulin Establishes a Potentially Curative Stem Cell-Directed Therapy for Myeloproliferative Neoplasms

Daniel C. Choi, Giovanni Medico, Irina V. Lebedeva…·Joseph Michael Scandura

This study demonstrates that CAR-T cells targeting mutant calreticulin can eliminate MPN-propagating HSCs in xenograft models without antigen escape.

1 citation

humanproteomics

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NeuroscienceCell Death and DiseasePeer-reviewedAug 5, 2021

Precision genetic cellular models identify therapies protective against endoplasmic reticulum stress

Irina V. Lebedeva, Michelle V. Wagner, Sunil Sahdeo…·David B. Goldstein

The paper identifies compounds that correct aberrant molecular phenotypes in cellular models of glycosylation defects using a phenotypic screening approach.

11 citations

humanbulk RNA-seq

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