Kappa Opioid Receptor Antagonism Restores Phosphorylation, Trafficking and Behavior induced by a Disease Associated Dopamine Transporter Variant
Felix P. Mayer, Adele Stewart, Durairaj Ragu Varman, Amy E. Moritz, James D. Foster, Anthony W. Owens, Lorena Bianchine Areal, Raajaram Gowrishankar, Michelle Velez, Kyria Wickham, Hannah Phelps, Rania M. Katamish, Maximilian J. Rabil, Lankupalle Damodara Jayanthi, Roxanne A. Vaughan, , Sammanda Ramamoorthy
This study shows that KOR antagonism restores phosphorylation, trafficking, and behavior in a mouse model with a disease-associated DAT variant.
Molecular Psychiatry · May 29, 2025Peer-reviewedNeuroscience