Durairaj Ragu Varman

Kappa Opioid Receptor Antagonism Restores Phosphorylation, Trafficking and Behavior induced by a Disease Associated Dopamine Transporter Variant

This study shows that KOR antagonism restores phosphorylation, trafficking, and behavior in a mouse model with a disease-associated DAT variant.

Dopamine transporter threonine-53 phosphorylation dictates kappa opioid receptor mediated locomotor suppression and conditioned place aversion via transporter upregulation

This study shows that phosphorylation of dopamine transporter at threonine-53 (pT53-DAT) mediates KOR agonist-induced locomotor suppression and aversion by enhancing DAT activity and surface expression.

A mutation in Hnrnph1 that decreases methamphetamine-induced reinforcement, reward, and dopamine release and increases synaptosomal hnRNP H and mitochondrial proteins

This study identifies a mutation in Hnrnph1 that reduces methamphetamine-induced reinforcement, reward, and dopamine release while increasing synaptic hnRNP H and mitochondrial proteins in mice.