Raajaram Gowrishankar

This study shows that KOR antagonism restores phosphorylation, trafficking, and behavior in a mouse model with a disease-associated DAT variant.

This paper identifies PdCO as a bistable GPCR with high temporal precision for optogenetic control of neural circuits in vivo.

This study identifies the role of endogenous dynorphin release in the dorsal striatum in regulating goal-directed behavior through retrograde GPCR inhibition.

The paper introduces OHRBETS, an open-source platform for head-fixed behavioral experiments in mice, demonstrating operant conditioning and dopamine signaling during reward tasks.

The paper identifies how specific neurons in the medial accumbens shell encode reward preference and show distinct roles in driving reward behavior.

The paper investigates sex-specific effects of a dopamine transporter variant on behavior and identifies sex-dependent circuit-specific regulation of dopamine signaling.