Sammanda Ramamoorthy

This study shows that KOR activation leads to DAT tolerance to cocaine via phosphorylation at threonine 53, demonstrated through behavioral, electrophysiological, and genetic experiments across species.

This study shows that KOR antagonism restores phosphorylation, trafficking, and behavior in a mouse model with a disease-associated DAT variant.

This study shows that phosphorylation of dopamine transporter at threonine-53 (pT53-DAT) mediates KOR agonist-induced locomotor suppression and aversion by enhancing DAT activity and surface expression.

This study identifies a mutation in Hnrnph1 that reduces methamphetamine-induced reinforcement, reward, and dopamine release while increasing synaptic hnRNP H and mitochondrial proteins in mice.